New technological trends in bioproduction

This activity identifies the main drivers of innovation in bioproduction—process robustness, market demand, cost, environmental impact, and regulatory constraints—and explains the steps required to implement these changes.

This activity explores four major innovations in bioprocess development:the improvement of culture media toward chemically defined compositions,process intensification using chromatographic membranes,equipment miniaturization to facilitate characterization studies,and the adoption of single-use equipment to reduce cleaning times and increase flexibility.These innovations aim to enhance process robustness, improve productivity, and meet both regulatory and environmental requirements.

This activity presents the contributions of digitalization in bioproduction facilities through the key concepts of Industry 4.0 (automation, sensors, etc.).It highlights concrete benefits such as productivity, flexibility, sustainability, and competitiveness, while also addressing challenges related to investment, cybersecurity, and required skills.The objective is to illustrate how digitalization is transforming manufacturing practices into smart, integrated, and data-driven systems.